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Key to the formation of permeable channels at the mitochondria are the Bcl-2 family members, a group of proteins that act as either pro-apoptotic (BAK, BAX, and BOK) or pro-survival (Bcl-2, Bcl-XL, and Mcl-1) inducers 44,45

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hemolysis?, no clear evidence of hemolysis

Direct electron transfer from the low-potential carriers to dioxygen would not only generate heat rather than conserving energy but would also generate reactive dioxygen species deleterious to the cell

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However, considering a multitude of physiological and pathological roles of CD44 [107,108], the mechanism of CD44-driven increase in susceptibility to APAP toxicity may be multifactorial and requires further investigation to determine