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STAT1, signal transducer and activator of transcription 1

Although the drop in hepatic or renal GSH is the most toxicologically relevant interaction (see also below), plasma GSH, free cysteine (Burgunder et al., 1989), and antioxidant capacity (Nuttall et al., 2003) were significantly reduced after a single 2 g PAC administration or 14 days of therapeutic doses of PAC in human volunteers, respectively

Kouki A, Ferjani W, Ghanem-Boughanmi N, Ben-Attia M, Dang PM, Souli A, et al

Neutrophil-derived cytokines, chemokines, proteases and reactive oxygen species, together with macrophage mediators, amplify local inflammation, whereas neutrophil or macrophage apoptosis and polarisation toward M2 macrophages promote resolution and tissue repair

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