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Recently, different in vitro and in vivo studies reported sepsis-induced changes in the shape of human erythrocytes, which have also been confirmed in animal models and humans [126, 381,382,383,384,385,386,387,388,389]

Notably, microglia from 1LPS- and 4LPS-treated mice exhibit distinct levels of H3K4me1 and H3K27ac, suggesting that epigenetic remodeling plays a key role in trained immunityassociated microglial plasticity (123)