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To conduct pull-down experiments for proteomic analysis of interacting proteins, we modified the macrocycles to include a FLAG-tag

Afterward, visualization of the relevant results was accomplished via the Bioinformatics online platform

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Cagrilintide is a long-acting amylin analogue that antagonizes endogenous amylin and calcitonin receptors, a drug currently being investigated for weight loss

The bioavailability difference is real and meaningful

Similarly, compounds from the spiro-oxindole dihydroquinazolinone series identified in the screening, e.g., 42 are weak inhibitors and besides that not stable in in vitro assays