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Much of the research on ROS production and redox regulation in the 1970s and 1980s was focused on the chloroplast, and the paper by Foyer and Halliwell (1976) shone a light firmly on ascorbate and glutathione specifically within this compartment

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This targeted approach, selecting drugs to precisely disrupt key nodes like GPX4 within the ferroptosis pathway, is a cornerstone of current therapeutic strategies against GBM