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[DOI] [PMC free article] [PubMed] [Google Scholar] Daud MK, Mei L, Azizullah A, Dawood M, Ali I, Mahmood Q, Ullah W, Jamil M, Zhu SJ

Few specific preventive and therapeutic options exist and there is an urgent need to seek novel effective approaches to reduce the incidence and severity of hepatic I/R injury-induced AKI

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Insulin, a crucial signal rapidly initiated in response to elevated postprandial blood sugar levels, plays a significant role in this regulatory network 114

The protection against MPP-induced neurotoxicity was associated with activation of Nrf2 pathway (a crucial defense mechanism against oxidative stress), via the ERK1/2 signaling pathway [57], inhibition of the mitochondrial ROS-dependent oxidative stress, and enhancement of the Erk1/2/Drp1 and Fak/Akt/GSK3 signaling pathways [104]