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NAC works differently as a modified amino acidspecifically an acetylated form of cysteine with the molecular formula C5H9NO3S and molecular weight of 163.19 g/mol

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Briefly, L02 cells were transfected with pcDNA3.1(+) or GSTA1 plasmids and incubated for 48 h

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Therefore, finding specific biomarkers of ferroptosis is still an urgent problem to be solved

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Increased PTMs of mitochondrial proteins inactivate many enzymes involved in the reduction of oxidative species, fatty acid metabolism, and mitophagy pathways, leading to mitochondrial dysfunction, energy depletion, and apoptosis

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As a result, oxidative protein folding in the endoplasmic reticulum is accompanied by the formation of hydrogen peroxide

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