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We are investigating the participation of NME isoforms in rapid localized synthesis of GTP from ATP [46, 67] because of their involvement in GTP-driven vesicular trafficking along microtubules [68], in aging, and AD

IL-1 can enhance the neuronal production of A and induce protein phosphorylation, the blocking of which can alleviate neuroinflammation by reducing A levels and activation (94,95)

Emerging research indicates that BSPs demonstrate significant anti-inflammatory effects through profound immunomodulation, characterized by the suppression of core inflammatory signaling pathways, a marked reduction in pro-inflammatory cytokine production, and the potentiation of anti-inflammatory mediators

For example, superoxide dismutase (SOD) converts O 2 into the relatively less reactive HO [46]

10.1038/nrn2038 11 BottinoF.LucignaniM.NapolitanoA.DellepianeF.ViscontiE.Rossi EspagnetM

Similarly, Duperray et al