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Using these data, we conducted a large genome-wide association study (GWAS), and identified robust evidence that variants in the GLP1R locus are associated with both differential weight loss and side effects

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Helmbacher et al., 2003)

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33,34 Of the Smads, Smad2 and Smad3 have been shown to be the major downstream regulators involved in TGF-1-mediated tissue fibrosis

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