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biochemically, there is intracellular glutathione (GSH) depletion and decreased activity of glutathione peroxidase 4 (GPX4), lipid peroxides cannot be metabolized by the GPX4-catalyzed reduction reaction, and Fe 2+ oxidizes lipids in a Fenton-like manner, resulting in a large amount of ROS, which promotes ferroptosis 3,6

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Furthermore, other cysteine residues (e.g., Cys226, Cys613, and His225) are involved in the sensing function of Keap1 and are necessary for detecting Cd 2+ , As 3+ , Se 4+ , and Zn 2+ [45, 50]

Development 126 , 41654173 (1999)

Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically relevant concentrations