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Comprehensive preclinical safety evaluations across multiple animal models demonstrate favorable tolerability profiles with excellent safety margins for investigational research applications

fermentum LM1016-treated mice compared with vehicle-treated mice (Fig

The peptide demonstrates tissue remodeling effects that may help reorganize scar tissue

1A and Fig

doi:10.1016/j.maturitas.2016.04.006 Moscatelli F, Monda A, Messina G, et al

AAV-shChac2 delivery alleviated systemic inflammation and improved metabolic outcomes in diabetic mice Based on the well-established clinical and experimental association between periodontitis and diabetes, 41,42,43,44,45,46,47 diabetes was used as a representative comorbidity model to assess the systemic impact of periodontitis-induced neutrophil reprogramming
