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Then 500 L of RBC suspension and 85 L of FITC labeled aCTLA-4 (aCTLA-4-FITC, 5 mg/mL) were mixed and dialyzed (3.5 kD MWCO) against 40 mL of hypotonic buffer (deionized water containing 10 mM NaHCO 3 , 10 mM NaH 2 PO 4 , 20 mM glucose, 2 mM ATP, and 3 mM reduced glutathione (GSH)) at 4 C for 90 min

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Careful titration of JUXTAPID may then be considered based on LDL-C response and safety/tolerability to half the maximum recommended dosage except when co-administered with oral contraceptives only, in which case the maximum recommended JUXTAPID dosage is approximately two thirds of the maximum recommended dosage (Table 3) [see Dosage and Administration (2.4), Warnings and Precautions (5.6), and Clinical Pharmacology (12.3)]

Others report no noticeable effects despite weeks of consistent use