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Elevated cortisol levels from stress can lead to skin sensitivity, breakouts, and inflammation, which often result in post-inflammatory hyperpigmentation (PIH)

9), indicating GPX4 deficiency potentiates oxidative stress and its feedback loop with GSDMD

The role of ferroptosis in PDAC is context-dependent and exhibits a stark duality

789 Tyrosine kinase Eph receptor A4 (EphA4) is notably expressed in the nervous system

This data supports the use of these compounds to mitigate the severe inflammatory cascades triggered by physical exertion in patients with post-exertional malaise (PEM)

Finally, considering the increasing prevalence of chronic kidney disease worldwide and that most of the complications following GBCA exposure are associated with renal dysfunction, the mechanisms underlying GBCA toxicity, especially renal toxicity, need further research studies