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[3] World Health Organization limits are up to 0.1 mg/L for drinking water levels and total lifetime oral intake of 10 g for no observable adverse effect levels

Reaction: NADPH + Methionine Adenosyltransferase (MAT-III) Methionine Adenosyltransferase (MAT-I) + NADP+ Importance: MTRR ensures the continuous synthesis of SAM by regenerating the active form of MAT, which catalyzes the formation of SAM from methionine and ATP

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