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Most patients with depression exhibit significant nutrient deficiencies

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Bastianetto S, Quirion R (2004) Natural antioxidants and neurodegenerative diseases

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Aptamers such as Macugen were developed as antiangiogenic agents that bind human VEGF-A to prevent signaling via VEGF receptors, thus inhibiting activation of a downstream signaling cascade to inhibit pathological angiogenesis 44

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