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A novel systematic and personalized treatment approach is suggested, combining the available medications and targeting each symptom accordingly

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Consequently, this high level of heterogeneity may limit the reliability and generalizability of the findings, potentially limiting the overall conclusions that can be drawn from the meta-analysis

As a result, the tear film becomes more prone to evaporation, leading to an increased concentration of solutes in the remaining tears, which finally results in the development of THO-dependent pathological changes [16,65]

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