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The levels of asiatic acid and madecassic acid in mice were found to increase significantly in the plasma, brain, heart, liver, kidney, colon, and bladder after 8 weeks of oral administration, compared to 4 weeks of administration [26]

3.2.4 Failure of immune homeostasis regulation mechanism The failure of immune homeostasis regulation mechanisms further contributes to excessive inflammation. The compensatory insufficiency or functional defect in anti-inflammatory factors constitutes a key feature of immune homeostasis imbalance during the acute phase of MPP

albicans cells, and the supernatants were used for the analysis of extracellular metabolites