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Description

Low-grade neuroinflammation as indexed by heightened levels of pro-inflammatory mediators (e.g., TNF-, IL-1, and COX-2) and activation of astrocytes and microglia, main immune cells in the brain, was observed in the hippocampus and piriform cortex regions of the brain of chronic sleep-deprived rats along with neurobehavioral alterations (anxiety, learning, and memory impairments) 136

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doi: 10.1038/sj.bjp.0703392 47

Calendar year Calendar year (as of 12/31/2025) Growth of $10,000 Growth of a $10,000 investment (as of 6/30/2026) This chart shows the value of a hypothetical $10,000 investment in the fund over the specified time period up to 10 years or since its inception (for funds lacking 10-year records)