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He says the product manufacturers "have figured out how to deliver more nicotine to young people than the cigarette manufacturers ever did," so they can be highly addictive

Microencapsulation functions as a shielding strategy, protecting sensitive compounds from degradation by environmental factors, including oxygen, temperature fluctuations, moisture, enzymes, and gastric acids (288)

Accordingly, the clinical presentations regarding liver involvement include a wide spectrum, ranging from asymptomatic subtle morphological changes, simple acute self-limited hepatitis-like illness to autoimmune-like hepatitis, or even recurrent jaundice (in the presence of haemolysis), cirrhosis with or without portal hypertension and even acute liver failure

Single-cell RNA sequencing studies have revealed that bioactive compounds can induce cell-type-specific transcriptional responses in neurons, astrocytes, and microglia, highlighting the complexity of nutrigenomic effects in the post-stroke brain (189)

Bortezomib before and after autologous stem cell transplantation overcomes the negative prognostic impact of renal impairment in newly diagnosed multiple myeloma: a subgroup analysis from the HOVON-65/GMMG-HD4 trial