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Description
If a reaction occurs within minutes or hours after contact with the substance, it indicates an immediate-type hypersensitivity reaction, indicating an allergy is present

Do They Help

For example, Raymo et al

Blood samples were collected by venipuncture in Vacutainer CPT Mononuclear Cell Preparation Tubes (BD, Franklin Lakes, NJ) with sodium heparin, immediately placed in ice water, and then centrifuged at 2,000 g at 4C for 10 min

10.1038/nn1395 19

Duration may vary slightly depending on the package selected and individual factors
