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doi: 10.1016/j.jclinepi.2011.01.011

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By directly activating melatonin receptors, scavenging free radicals, or increasing the availability of nitric oxide in the central nervous system, melatonin also reduces sympathetic tone

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Accordingly, an improved understanding in humans of the microbial pathways involved in TMA/TMAO formation from distinct nutrients is an essential and necessary step in the development of targeted interventions to interrupt these processes
