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In addition, if a biomarker of oxidative stress is particularly relevant from a pathophysiological point of view, it may also be useful in research as a therapeutic target to identify novel treatments with antioxidant properties

10.1038/ncb2220 21 GuarnieriG.SitulinR.BioloG

However, one of its causes can be due to a prolonged and sustained inflammatory response, triggered by trauma, which allows extravascular protein deposition, inflammatory cell recruitment, fibrin deposition on the expression of inflammatory cytosines, and release of elastase 1 , which leads to a change of type I collagen into type III collagen