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KD fed SOD1-G93A transgenic ALS mice lost 50% of baseline motor performance 25 days later than the disease controls through the gain in mitochondrial energy production (164)

This article reports an accelerated discovery approach for ionizable lipids for RNA delivery using combinatorial chemistry

Over time, research has shifted toward stronger or more multifunctional co-stimulatory ligands, like CD40L, which not only activate T cells but also directly license DCs and promote cytokine production

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