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This manuscript mainly reviewed the existing evidences suggesting the opposite role of apoC3 and apoA5 in lipid metabolism and CAD risk, and discussed potential correlation between these two apolipoproteins

The first pathway involves remethylation catalyzed by the vitamin B 12 -dependent methionine synthase, which captures a methyl group from the folate-dependent one-carbon pool (5-methyltetrahydrofolate)

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Activated TGF-RI then recruits and phosphorylates the downstream signaling molecules SMAD family members SMAD2 and/or SMAD3, which subsequently combine with SMAD4 to form a heterotrimeric complex

[48,49] Though the exact mechanism through which chromium impacts insulin is still unknown, one mechanism is thought to relate to this chromium-chromodulin interaction

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