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PMID: 41203627 Cell Rep Microglial macrophage-derived ds-HMGB1 in DRG orchestrates neuropathic pain through immune-neural signaling

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All these points support the further targets (i.e., smooth muscle, i.e., pupil [86], or lower esophageal sphincter and pyloric sphincter [92] and urethral sphincter [100], and blood vessel [122]) sensitivity to NOS-blockade or NOS-over activity that can be distinctive

Accordingly, the identified M-QTLs are best interpreted as integrative, trait-weighted genomic regions rather than uniform tolerance loci, and trait-resolved M-QTL analyses remain an important avenue for future refinement