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Mitochondrial dysfunction and oxidative stress are often implicated in progressive neurodegenerative disorders such Alzheimers disease and Parkinsons disease and in damage secondary to TBI.5,6 Additionally, new research both in vitro and in mice has suggests that methylene blue may reduce neuronal apoptosis and improve blood-brain barrier integrity.7 One randomized, blinded, placebo-controlled trial evaluated the effects of methylene blue 10mg/kg administered intraperitonially to mice and rats immediately or 24 hours post ischemic stroke

In particular, neurons often accumulate more Mn, with Mn signals reported predominantly in the nucleus and cytosol and, surprisingly, little in the mitochondria

"Until now, the only real therapy for patients has been a lifetime of insulin replacement

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Type 2 diabetes mellitus is characterized by chronic hyperglycemia resulting from insulin resistance, amyloid deposition, pancreatic -cell dysfunction, and impaired glucose regulation (371, 372)

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