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doi:10.1007/s10637-014-0189-z

In colorectal cancer (CRC) cell lines, dusigitumab neutralized IGF-2 and induced significant tumor growth inhibition in mouse models that overexpressed IGF-2, a finding that supports evaluation of dusigitumab in CRC patients whose tumors overexpress IGF-2 [128]

Hertel S, Pohl T, Friess W, Winter G

Glutathione transferases, regulators of cellular metabolism and physiology

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