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Nature Reviews Drug Discovery 23 , 98 (2024) doi: Competing Interests The authors of this article are employees of The Boston Consulting Group (BCG), a management consultancy that works with the world's leading biopharmaceutical companies

2 The mechanism of ferroptosis and iron homeostasis The critical molecular mechanism of ferroptosis involves regulating the balance between oxidative damage and antioxidant defense ( Intracellular iron accumulation is a key factor in ferroptosis, attributed to several fundamental processes of cellular metabolism