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Aspartame was discovered accidently in the 1960s, by chemist James Schlatter while working on an anti-ulcer medication, it was approved as a food additive in the 1980s

14 Government and prominent non-profit health organizations, such as the American Cancer Society (ACS) and the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR), have issued guidelines and recommendations for cancer prevention since the 1980s, with a focus on weight management, physical activity, diet, and alcohol consumption

doi: 10.1016/S0169-328X(01)00108-5

For muscle protein synthesis, this protein-derived insulin response appears sufficient

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Role of reactive oxygen species in apoptosis: implications for cancer therapy