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In the phase 3 randomized, double-blind, multicenter, placebo-controlled REDEFINE 1 and REDEFINE 2 clinical trials, conducted over 68 weeks, CagriSema (Novo Nordisk)a once-weekly combination therapy of the weight-loss medications semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, and cagrilintide, an amylin analogdemonstrated significant weight loss and metabolic improvements compared with placebo

Decreased filaggrin concentrations support the theory that significant overlap exists between the mucosal structure of the skin and the mucosal structure of the esophagus (Blanchard et al

doi: 10.1016/j.cub.2004.12.057 66 DuSLingHGuoZCaoQSongC

PCSK9 plays a key role in enhancing LDLR degradation through a clathrin and low density lipoprotein receptor adapter protein 1 (LDLRAP1)-mediated pathway

doi: 10.1016/j.coph.2015.10.009 101 HughesDAPinderACPiperZLundEK

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