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Pannexin-1 channels are increasingly recognized as conduits for ATP release, and experimental blockade of Panx1 has been shown to attenuate peripheral inflammatory pain, underscoring their contribution to nociceptive amplification when inflammation is present [43,45]

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Renal, Liver and Heart Histology The renal injury criteria were based on the degeneration of Bowmans space and glomeruli, degeneration of the proximal and distal tubules, vascular congestion, and interstitial oedema