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Athleten, die WADA-konformen Tests unterliegen, sollten es dennoch als verboten behandeln

Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

doi: 10.1016/j.bbi.2014.10.007

, Reference Suomivuori2020)

Cautious use of parenteral cyanocobalamin is also recommended in patients with renal impairment, including premature neonates, because of the possibility of greater aluminum accumulation, which may cause central nervous system and bone toxicity

Research on Dihexas effects on dementia and age-related cognitive decline is still in its early stages