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Cyril C, Rai P, Chandra N, Gopinath PM, Satyamoorthy K

In addition, SQSTM1 can recognize ubiquitinated Parkin, a key protein of mitophagy, and disrupted SQSTM1 mediates mitophagy deficiency (Song et al., 2016), which is an important cause of PD

92 Thus, it appears that dynamic cross-talk between epithelial and immune cell homeostasis maintains normal gut functioning, and that disruption of any of these factors seems capable of inducing conditions favoring an inflammatory environment
