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This results in an increase in a number of major microbial-derived uremic toxins (Table 1), including indoxyl sulphate (IS), indole-3-acetic acid (IAA), p-cresyl sulphate (PCS) and trimethylamine-N-oxide (TMAO) [15, 70, 71]

However, passive targeting frequently lacks precision and offers limited spatiotemporal control

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CORRELATION BETWEEN PATIENT HANDLING ERRORS AND INVITRO PERFORMANCE OF SPIRIVA HANDIHALER Jetmir Xhema1, Line Tschiember1 & Yannick Baschung1 1OINDP analytical services, Solvias AG, Kaiseraugst, Switzerland Summary: Success of inhalation therapy highly correlates with appropriate and reproducible doses delivered to the lungs, and correct inhaler technique are key for successful treatment outcome