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Five clinical trials involving adult patients have been evaluated in a systematic review with positive results (100)

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[DOI] [PubMed] [Google Scholar] 33.Guo CH, Hsu GS, Chuang CJ, Chen PC

Chemotherapy-Induced Distal Enhancers Drive Transcriptional Programs to Maintain the Chemoresistant State in Ovarian Cancer

When cells are under oxidative stress, proteins containing the pentapeptide sequence are unfolded to expose the sequence for binding with constitutive heat shock protein 70 (HSC70) [105]

Frequency: 2 to 3 times daily, typically before bed plus one or two additional doses
