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In these individuals it would appear that whilst they were able to exist as relatively healthy individuals, often not knowing that they had methylation associated mutations, some initiating factor such as a prolonged infection, combined with low vitamin D levels resulted in gradual loss of their vitamin B12 supplies leading to the CFS symptomatology being apparent, and the subsequent discovery of their methylation status

Immediate relief of symptoms post exercise

Transl Psychiatry 14(1):367

The key is maintaining a clear line between legitimate, ethical research and the prohibited use of these substances for performance enhancement

From there, the research expanded - first to other tissues, then to various injury models in rodents

IV therapy delivers nutrients directly into the bloodstream, allowing for higher bioavailability and more immediate effects