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In addition, as noted above, most item nonresponse was addressed using hot-deck imputation methods and random imputation for a few items when applicable

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Understanding immunosenescence and its impact on vaccination of older adults

ATR inhibitor AZD6738 and WEE1 inhibitor AZD1775 inactivated RAD51-mediated homologous recombination [359], activated cyclin-dependent kinase 1 (CDK1) activity, forced DNA-damaged cells into mitosis, and induced serious mitotic abnormalities and mitotic catastrophes, eventually resulting in TNBC cell death, and improving the sensitivity of TNBC to cisplatin and PARP inhibitors [360, 361]

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This development carries real implications for patients, providers, and the broader wellness community