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UV radiation (UVR) exposure can activate the cutaneous immune system by releasing pro-inflammatory factors, ROS, and inducing apoptosis in keratinocytes, thereby causing sterile inflammation or cancer (Tang et al., 2021)

Curcumol exhibits anti-inflammatory properties by interfering with the JNK-mediated AP-1 pathway in lipopolysaccharide-activated RAW264

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Numerous metabolites, such as lipopolysaccharide (LPS), bile acids, trimethylamine N-oxide, and short-chain fatty acids have been linked to gut microbiomes and diseases, as supported by evidence [28, 29]

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