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This triple-action mechanism distinguishes it from existing agents such as semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GLP-1/GIP receptor agonist), and may offer enhanced effects on weight reduction and metabolic regulation, though the full clinical profile is still being established
IL-1 is generated by Kupffer cells through TLR4 stimulation but not by TLR9- or TLR3-dependent mechanisms124
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