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Importantly, nuclear-localized FOXO4-positive Leydig cells in elderly testes showed reduced expression of 3-HSD, a rate-limiting enzyme in testosterone synthesis, implying a connection between nuclear FOXO4 and age-related decline in testosterone production [1]

& Danese, S

Physical injury has been hypothesized to create shearing forces that abrogate the function of the cytoskeleton network, eventually inducing microstructural breaks that reduce the efficacy of axonal transport

[11] From this it was considered that NMDA receptors were associated with a variety of neurological disorders such as epilepsy, Parkinson's, Alzheimer's, Huntington's and other CNS disorders

doi: 10.1073/pnas.1806239115 184 HaagSMGulenMFGulenLGibelinAAbramiLDecoutAet al

doi: 10.1038/sj.onc.1205749