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Because the amount of spine elimination is more than two-fold higher than that of spine formation between adolescence and adulthood, these in vivo studies indicate that the net spine loss observed in fixed tissue is mainly due to the elimination, also called pruning, of existing synaptic connections

10.1053/j.gastro.2019.01.253 58

Think of it as a massive electrical cable

Understanding why requires knowing what B12 actually does