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Injury to brain tissue may increase CK-1 activity in CSF, but rarely results in raised total serum CK activity

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Current lipid-based RNA delivery systems, such as LNPs have drawn inspiration from conventional liposomal systems, notably the Doxil formulation, which was the first FDA-approved nanomedicine (Barenholz, 2012)

Robinson RA, Lange MB, Sultana R, Galvan V, Fombonne J, Gorostiza O, Zhang J, Warrier G, Cai J, Pierce WM, Bredesen DE, Butterfield DA