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designed a prodrug form (JHU083) of the glutamine antagonist DON, administered in an inert state but then preferentially activated by enzymes enriched in the tumor microenvironment [72]

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3.2 T cells in DKD pathogenesis T lymphocytes, which originate from bone marrow progenitors and differentiate in the thymus, consist of heterogeneous subsets such as CD4+ helper T cells (Th), cytotoxic CD8+ T cells (CTLs), and Tregs (61)

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