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The implications of NNMT inhibition extend far beyond simple cofactor availability, influencing fundamental cellular processes including mitochondrial biogenesis, oxidative stress management, and epigenetic regulation
Metabolic Rewiring: By stopping the conversion of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA), the cell is forced to recycle NAM into NAD+
Side effects are uncommon and typically limited to mild injection site reactions
Promotes Metabolic Flexibility Helps the body switch efficiently between carbohydrate and fat energy sources
Journal of Pharmaceutical and Biomedical Analysis 204:114255
