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PMID: 38969654): NNMT inhibition alone improved grip strength by 40% in aged sedentary mice Combined with exercise, grip strength improved by 60% over sedentary controls Proteomic and metabolomic analyses revealed distinct molecular mechanisms from exercise Related Reading# Stay current on 5-Amino-1MQ research We summarize new studies, safety updates, and dosing insights delivered biweekly

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Importantly, treatment of DIO mice with our NNMT inhibitors did not impact food intake, but produced marked reductions in body weight, WAT mass, adipocyte size, and cholesterol levels with negligible toxicity or observable adverse effects