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Moreover, future research plans include employing conditional knockout mouse models to more comprehensively and deeply assess the neuroprotective effects mediated by SIRT1

The empirical solubility measurements showed approximately 102 folds higher aqueous solubility for the glutathione-epothilone conjugate (0.127 mg/ml) compared to unmodified Epothilone (0.00125 mg/ml)

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In concordance, transgenic mice overexpressing IL-6 in the CNS display increased stress-induced glucocorticoid levels, likely inducing vulnerability to depressive-like behaviors[118]

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