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Mechanistically, leptin up-regulates CBS expression through FOXO3a, promotes pre-TRH production by inhibiting the mTOR pathway, and then increases TH production and decreases corticosterone production, thus reducing fat deposition and improving insulin resistance induced by FHD (74)

Front Plant Sci 4:506

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Chan RCK, Di X, McAlonan GM, Gong QY

It plays a key role in antioxidant defense, the breakdown of nutrients, and regulation of many biological processes (including immune response & improving insulin sensitivity)