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One of the approaches to enhance soluble expression is co-expression of protein chaperones [14]

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[11] M.-J

By contrast, the number of GFAP + cells in the ROT + SP and ROT + MH groups was significantly lower than that of the ROT group [SP: 29.08 4.81 ( P = 1.16 \(\times 10\) 6 ) and MH: 26.89 8.87 ( P = 2.23 \(\times 10\) 5 )]

Based on the preclinical and clinical trials translated from molecular studies, new options are being developed for sequencing and combination treatment using many types of endocrine modulators such as AIs or ER downregulators