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doi:10.1016/j.cll.2006.02.003

The oxidative milleu enhances ECM stability and stiffness through the upregulation of enzymes like lysyl oxidases (LOX and LOXL2), which catalyzes the crosslinking of collagen and elastin fibers, increasing EMC tensile strength (127, 128)

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Pain Modulation GHK-Cu also interacts with opioid and cannabinoid receptors, offering a natural form of analgesia (PMID: 22854480)

Experimental evidence from laboratory studies suggests that FT-C60 exhibits antioxidant and anti-inflammatory properties, which may help alleviate intervertebral degeneration-associated low back pain in animal models

They found M2-type macrophages to be more sensitive than M1-type macrophages to ferroptosis