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So, theres promoter region hypermethylation thats associated with many disease processes, most well studied cancer, so these promoter regions are shut down, tumor suppressor genes are also shut down

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SAMe donates methyl groups to DNA, RNA, and proteins, producing S-adenosyl-homocysteine (SAH)

doi: 10.1016/0006-2952(86)90527-7

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Retinitis pigmentosa: novel therapeutic targets and drug development